Antimicrobial activities of cinnamyl rifamycin derivatives, T-9 and T-11, against Mycobacterium tuberculosis and Mycobacterium avium complex (MAC) with special reference to the activities against intracellular MAC

The mycobacterial activities of cinamyl rifamycin derivatives, T-9 and T-11, especially against extracellular and intracellular Mycobacterium avium complex residing within macrophages and type 11 pneumocytes were compared with those of other rifamycins. The activities of test irifamycins were found to be in the order rifalazil, rifabutin, T-9, T-11, and rifampicin.