Solubilization of non-steroidal anti-inflammatory drugs in the presence of tween series surfactants

The aqueous solubility of non-steroidal anti-inflammatory drugs (NSAIDs) Ketoprofen, Ibuprofen, Diflunisal and Naproxen were measured in the presence of the Tween series surfactants at 37 degrees C. Results showed that the solubility of NSAIDs in the Tween solutions was approximately proportional to Tween concentration; the ability of Tween series surfactants to solubilize NSAIDs in the present study was Tween-80> Tween-60> Tween-40> Tween-20; the order of increased solubility of NSAIDs in Tween series surfactants at a constant Tween series and concentration was Ibuprofen > Ketoprofen > Diflunisal > Naproxen. Under suitable conditions Tween series surfactants can be highly effective used to enhance the solubility of NSAIDs.