期刊
SIAM JOURNAL ON APPLIED MATHEMATICS
卷 66, 期 6, 页码 2049-2060出版社
SIAM PUBLICATIONS
DOI: 10.1137/060657121
关键词
cellular traction; linear elasticity; inverse problem; finite element
The evaluation of the traction exerted by a cell on a planar substrate is here considered as an inverse problem: shear stress is calculated on the basis of the measurement of the deformation of the underlying gel layer. The adjoint problem of the direct two-dimensional plain stress operator is derived by a suitable minimization requirement. The resulting coupled systems of elliptic partial differential equations (the direct and the adjoint problem) are solved by a finite element method and tested against experimental measures of displacement induced by a fibroblast cell's traction.
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