期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 17, 期 6, 页码 631-643出版社
VSP BV
DOI: 10.1163/156856206777346287
关键词
electrospinning; poly(vinyl alcohol); polyethylenimine; poly(D,L-lactide); composite membrane
Ultra-fine fibers of poly(vinyl alcohol)/polyethylenimine (PVA/PEI) were prepared by electrospinning of their blend solutions in water. Effects of PVA/PEI mass ratio and the polymer concentration on the fiber morphology were discussed by analysis of scanning electron micrographs. Results showed that uniform ultra-fine fibers could be obtained from an 8% PVA/PEI solution with 75 : 25 mass ratio. It was supposed that the introduction of PVA could promote electrospinning of PEI by weakening the intermolecular interaction and increasing solution viscosity. A composite membrane of PVA/PEJ with poly(D,L-lactide) (PLA) was produced by co-electrospinning simultaneously from the aqueous 8% PVA/PEI (75: 25) solution and a 20% PLA solution in N',N-dimethylformamide in two separated syringes. Fourier transform infrared spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopy verified the existence of PVA/PEI and PLA in the fibrous membrane. We attempted to incorporate PEI with PLA as ultra-fine fibers to diminish the acidic inflammation caused by biodegradation of PLA. The fibrous composite membrane of PVA/PEI-PLA could provide better biocompatibility and would be used as drug-delivery carriers or tissue-engineering scaffolds.
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