期刊
ARCHIV DER PHARMAZIE
卷 339, 期 1, 页码 41-47出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.200500124
关键词
Vilsmeier-Haack reagent; beta-chlorocarboxaldehyde; pyrazolo[4,3-c]chromenes; thieno[3,2-c]chromenes; anti-inflammatory; analgesic
Some new aldazino 4, pyrazolo 5, thieno 8, and thiooxopyrimidino chromenes 10 were prepared via reaction of the corresponding beta-chlorocarboxaldehyde 3 with hydrazine hydrate, mercaptoacetic acid, and thiourea, respectively. Wherever, 4-chlorochromene derivatives 2 along with 4-chlorochromen-3-carboxaldehyde derivatives 3 were prepared from the corresponding ketone 1 with Vilsmeier-Haack reagent. Some of the new products showed good anti-inflammatory, analgesic, anticonvulsant, and antiparkinsonian activities comparable to indomethacin, diclofenace, carbamazepine, and benztropine.
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