期刊
CANCER DETECTION AND PREVENTION
卷 30, 期 6, 页码 481-490出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cdp.2006.10.008
关键词
nucleophosmin; phosphorylation; centrosome duplication; Ran/CRM1; nucleophosmin structure; CDK1/cyclin E; DNA replication; acute myeloid leukernia; myelodysplastic syndromes; cell proliferation
类别
资金
- NATIONAL CANCER INSTITUTE [Z01BC005793] Funding Source: NIH RePORTER
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [Z01 BC005793-11] Funding Source: Medline
Nucleophosmin (NPM) is a nucleolar phosphoprotein that shuttles between the nucleus and cytoplasm during the cell cycle. NPM has several interacting partners and diverse cellular functions, including the processing of ribosomal RNA, centrosome duplication and the control of cellular processes to ensure genomic stability. Subcellular localization of NPM appears to be strongly correlated with NPM functions and cell proliferation. NPM is phosphorylated mainly at its central acidic domain by several upstream kinases, and its phosphorylation appears to be involved in regulating its functions in ribosome biogenesis and centrosome duplication. Recent studies suggest that NPM may act as a licensing factor to maintain proper centrosome duplication and that the Ran/CRM1 nucleocytoplasmic complex regulates local trafficking of NPM to centrosomes by interacting through its nuclear export sequence motif. Here, we provide a brief overview of NPM functions and its roles in human carcinogenesis, and discuss our recent findings related to the potential mechanisms underlying its regulation of centrosome duplication. (c) 2006 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据