期刊
AAPS JOURNAL
卷 8, 期 1, 页码 E138-E145出版社
SPRINGER
DOI: 10.1208/aapsj080116
关键词
trace amine associated receptor; TAAR; mammalian; G-protein coupled receptor; ADHD; hypothyroidism-associated depression; prepulse inhibition
The discovery of a family of G-protein coupled receptors, some of which bind and are activated by biogenic trace amines, has prompted speculation as to the physiological role of these receptors. Observations associated with the distribution of these trace amine associated receptors (TAARs) suggest that they may be involved in depression, attention-deficit hyperactivity disorder, eating disorders, migraine headaches, and Parkinson's disease. Preliminary in vitro data, obtained using cloned receptors, also suggest a role for TAARs in the function of hallucinogens.
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