期刊
ANNALS OF BEHAVIORAL MEDICINE
卷 31, 期 2, 页码 165-172出版社
LAWRENCE ERLBAUM ASSOC INC
DOI: 10.1207/s15324796abm3102_8
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资金
- NCI NIH HHS [CA16058] Funding Source: Medline
- NCRR NIH HHS [M01-RR-0034] Funding Source: Medline
- NIA NIH HHS [P01 AG16321] Funding Source: Medline
- NIDCR NIH HHS [P50 DE13749] Funding Source: Medline
- NIMH NIH HHS [R37 MH42096] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA016058] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000034] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [P50DE013749] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R37MH042096] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG016321] Funding Source: NIH RePORTER
Background: Human and animal laboratory studies have shown that stress delays healing of standardized punch biopsy wounds. Purpose: This 5-week prospective study of 17 women who underwent elective gastric bypass surgery addressed the association between postsurgical pain intensity and subsequent healing of a standard 2.0-mm punch biopsy wound. Methods: Participants were assessed 1 week before surgery, within 3 hr before surgery, 1 to 3 days postsurgery, and at weekly intervals for 4 weeks following surgery. Results: Patient ratings of greater acute postsurgical pain, averaged over Days 1 and 2 postsurgery, and greater persistent postsurgical pain, averaged over 4 weekly postsurgery pain ratings, were significantly associated with subsequent delayed healing of the punch biopsy wound. Presence of depressive symptoms on the day of surgery, pre-existing persistent pain, and medical complications following initial discharge front the hospital were not related to wound healing. Depressive symptoms on the day of surgery and pre-existing persistent pain did predict persistent postsurgical pain intensity. Conclusions: These findings extend the previous laboratory models of wound healing to a surgical population, providing the first evidence that pain plays an important role in postsurgery wound healing, a key variable in postsurgical recovery.
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