期刊
ACTA HAEMATOLOGICA
卷 115, 期 1-2, 页码 74-77出版社
KARGER
DOI: 10.1159/000089470
关键词
aberrant phenotype; B-CLL; CD8; flow cytometry; immunophenotype; T cell antigen
类别
The expression of T cell-associated antigens on B cell non-Hodgkin lymphoma is rare. We describe 5 cases of B-chronic lymphocytic leukemia (B-CLL) with aberrant expression of CD8 on B cells. These B-CLL presented a typical immunophenotype CD19+, CD23+, FMC7- and CD5+ (except for 1 case) with a monotypic expression of surface immunoglobulin light chain kappa. The CD8 expression was confirmed on B-CLL cells by two-color flow cytometry staining. We could not find coexpression of CD3 or CD4 on B-CLL cells. The clinical implications, the sensitivity to therapy and the prognostic outcome of this aberrant expression remains to be determined. Copyright (C) 2006 S. Karger AG, Basel.
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