期刊
TRENDS IN IMMUNOLOGY
卷 27, 期 1, 页码 49-55出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2005.11.005
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资金
- NCRR NIH HHS [K12RR17594] Funding Source: Medline
- NIAID NIH HHS [N01AI50031, T32 AI007517] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [K12RR017594] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007517, N01AI50031, N01AI050031] Funding Source: NIH RePORTER
Toll-like receptors (TLRs) are a family of pattern-recognition receptors that are an important link between innate and adaptive immunity. Many established, as well as experimental, vaccines incorporate ligands for TLRs, not only to protect against infectious diseases but also in therapeutic immunization against noninfectious diseases, such as cancer. We review the underlying mechanisms by which engagement of TLR signaling pathways might trigger an adaptive immune response after immunization. Although the engagement of TLR signaling pathways is a promising mechanism for boosting vaccine responses, questions of efficacy, feasibility and safety remain the subject of active investigation.
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