期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 17, 期 1-2, 页码 3-19出版社
TAYLOR & FRANCIS LTD
DOI: 10.1163/156856206774879171
关键词
dendrimer; biomaterials; nanomedicine; drug delivery; polyamidoamine (PAMAM) dendrimer
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL077825] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL-077825] Funding Source: Medline
Dendrimers are a unique class of synthetic macromolecules having a highly branched, three-dimensional, nanoscale architecture with very low polydispersity and high functionality. Structural advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. This review discusses several aspects of dendrimers, including preparation, dendrimer-drug coupling chemistry, structural models of dendrimer-based drug delivery systems, and physicochemical and toxicological properties.
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