期刊
SEMINARS IN IMMUNOLOGY
卷 18, 期 3, 页码 167-175出版社
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2006.03.001
关键词
NK cell; NKG2D; signal transduction
类别
NKG2D is an important immunosurveillance receptor that triggers a unique signal transduction pathway resulting in a variety of functional outcomes. NKG2D couples to the non-ITAM-containing DAP10 and initiates at least two signaling branches that are both required for cytotoxicity. Transformed. infected, or healthy cells can express NKG2D ligands, and NKG2D(+) lymphocytes can be unaffected, costimulated, or fully activated by the NKG2D-ligand interaction. The NKG2D-mediated response can be modulated by factors such as cytokine milieu and possibly the particular ligand expressed. Thus, this nontraditional NKG2D-DAP10 initiated signal pathway enables lymphocytes to differentially respond to ligands based on the cellular environment. (C) 2006 Elsevier Ltd. All riahts reserved.
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