期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 1, 期 2, 页码 117-128出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/nano.2006.1.2.117
关键词
chitosan; oral delivery; nanoparticles
资金
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB002849] Funding Source: NIH RePORTER
- NIBIB NIH HHS [EB002849, R01 EB002849-01, R01 EB002849] Funding Source: Medline
Chitosan is a widely available, mucoadhesive polymer that is able to increase cellular permeability and improve the bioavailability of orally administered protein drugs. It can also be readily formed into nanoparticles able to entrap drugs or condense plasmid DNA. Studies on the formulation and oral delivery of such chitosan nanoparticles have demonstrated their efficacy in enhancing drug uptake and promoting gene expression. This review summarizes some of these findings and highlights the potential of chitosan as a component of oral delivery systems.
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