期刊
ANNALS OF MEDICINE
卷 38, 期 8, 页码 552-559出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/07853890600995010
关键词
cardiovascular and metabolic function; cardiovascular disease; central and peripheral clocks; circadian rhythms; chronotherapy; environmental stress
The molecular circadian clock entrains biological rhythms to a 24-hour schedule. Aspects of cardiovascular physiology and, indeed, the incidence of myocardial infarction and stroke are also subject to diurnal variation. The use of rodent models of disrupted clock function has begun to elucidate the role of the molecular clock in the pathophysiology of cardiovascular and metabolic disease.
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