期刊
METABOLIC ENGINEERING
卷 8, 期 1, 页码 46-57出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymben.2005.09.006
关键词
pathway design and optimization; elementary flux mode; sensitivity; operational constraints; Escherichia coli; succinate production
We have developed a pathway design and optimization scheme that accommodates genetically and/or environmentally derived operational constraints. We express the full set of theoretically optimal pathways in terms of the underlying elementary flux modes and then examine the sensitivity of the optimal yield to a wide class of physiological perturbations. Though the scheme is general it is best appreciated in a concrete context: we here take succinate production as our model system. The scheme produces novel pathway designs and leads to the construction of optimal succinate production pathway networks. The model predictions compare very favorably with experimental observations. (c) 2005 Elsevier Inc. All rights reserved.
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