期刊
IMMUNOLOGIC RESEARCH
卷 36, 期 1-3, 页码 137-146出版社
HUMANA PRESS INC
DOI: 10.1385/IR:36:1:137
关键词
dendric cells; cancer; immunotherapy; vaccines; Th1; CTL; NK cells; clinical trials; melanoma; colorectal cancer; prostate cancer
类别
资金
- NCI NIH HHS [1R01CA 095128, 1R01CA82016, 1P01CA 101944-01] Funding Source: Medline
- NIAID NIH HHS [R01 AI152655] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA095128, P01CA101944] Funding Source: NIH RePORTER
The work in our laboratory addresses two interrelated areas of dendritic cell (DC) biology: (1) the role of DCs as mediators of feedback interactions between NK cells, CD8(+) and CD4(+) T cells; and (2) the possibility to use such feedback and the paradigms derived from anti-viral responses, to promote the induction of therapeutic immunity against cancer. We observed that CD8(+) T cells and NK cells, the classical effector cells, also play helper roles, regulating ability of DCs to induce type-1 immune immunity, critical for fighting tumors and intracellular pathogens. Our work aims to delineate which pathways of NK and CD8(+) T cell activation result in their helper activity, and to identify the molecular mechanisms allowing them to induce type-1 polarized DCs (DC1s) with selectively enhanced ability to promote type-1 responses and anti-cancer immunity. The results of these studies allowed us and our colleagues to design phase I/II clinical trials incorporating the paradigms of DC polarization and helper activity of effector cells in cancer immunotherapy.
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