期刊
DRUG METABOLISM AND PHARMACOKINETICS
卷 21, 期 3, 页码 248-256出版社
JAP SOC STUDY XENOBIOTICS
DOI: 10.2133/dmpk.21.248
关键词
SLC29A1; ENT1; SNP; haplotype
Thirty-nine genetic variations, including thirty novel ones, were found in the human SLC29A1 gene, which encodes equilibrative nucleoside transporter 1, from 256 Japanese cancer patients administered gemcitabine. The found novel variations included -8166G > A, -8110A > G, -7947G > A, -7789T > C, -5595G > A, -3803(-)-3783delTCGGGGAGGTGGCAGTGGGCG, -3548G > C, -3414G > A, -1355T > C, -34C > G, IVS1+141G > A, IVS1+260C > T, IVS1-82C > T, 177C > G, IVS3 - 6C > T, 564C > T, IVS8 + 44T > C, IVS8 + 90T > C, IVS8 + 97T > C, IVS8 + 131C > T, IVS8+169G > A, 933T > C, 954C > T, IVS11-52G > C, IVS11-46G > A, 1288G > A, 1641C > G, 17031704delGT, 1812C > T, and 1861C > T. The frequencies were 0.051 for IVS8+ 169G > A, 0.012 for -7947G > A, 0.006 for IVS1+141G > A and 1703-1704delGT, 0.004 for - 8166G > A, - 8110A > G, - 3548G > C, - 1355T > C, - 34C > G, IVS8 + 44T > C, and 1812C > T, and 0.002 for the other 19 variations. Among them, 177C > G and 1288G > A resulted in amino acid substitutions Asp59Glu. and Ala430Thr, respectively. Using the detected polymorphisms, linkage disequilibrium analysis was performed, and 28 haplotypes were identified or inferred. Our findings would provide fundamental and useful information for genotyping SLC29A1 in the Japanese and probably other Asian populations.
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