期刊
IMMUNOLOGIC RESEARCH
卷 36, 期 1-3, 页码 127-136出版社
HUMANA PRESS INC
DOI: 10.1385/IR:36:1:127
关键词
skin immune system; dendritic cells; Langerhans cells; dermal denritic cells; c-type lectins; CD1 dendritic cell precursors; CD14
类别
资金
- NCI NIH HHS [R01CA100893] Funding Source: Medline
- NIAID NIH HHS [R21AI57958] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA100893] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI057958] Funding Source: NIH RePORTER
The skin functions as an important pro-inflammatory and immune organ. Accordingly, the epidermis and dermis are highly populated by dendritic cells (DC), which are potent anti gen-presenting cells (APC) with important immunostimulatory and migratory activities. Whereas the biological characteristics and immunological functions of epidermal DC known as Langernahs cells (LC) have been the focus of intense research in the past, less is known regarding their dermal counterparts named dermal dendritic cells (DDC). Although it has been widely accepted that LC are the more relevant skin-resident APC, recent experimental evidence challenges this concept and proposes a different role for these important cell populations. In this article we compile recent scientific advances regarding the function of different skin-resident DC and we try to reconcile the new observations with the previously established paradigm.
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