期刊
DEVELOPMENTAL NEUROSCIENCE
卷 28, 期 6, 页码 479-487出版社
KARGER
DOI: 10.1159/000095110
关键词
Mobp splice variants; MOBP protein isoforms; spatio-temporal gene expression; MOBP function; ectopic expression; experimental autoimmune encephalomyelitis, multiple sclerosis; MOBP-null strains
The myelin-associated oligodendrocytic basic protein (MOBP) family constitutes the third most abundant protein in CNS myelin. The mouse Mobp gene comprises eight exons. Mobp pre-mRNA processing gives rise to at least seven Mobp splice variants which are expressed solely in the oligodendrocyte. The predicted proteins all, with one exception, share a 68 residue amino terminus, encoded by exon 3. The carboxyl termini differ in length, giving rise to the diverse array of the protein isoforms. Like myelin basic protein, MOBP is present in the major dense line of CNS myelin suggesting a role in the compaction or stabilization of myelin. However, Mobp homozygous null mice display no overt clinical phenotype and no defect in the process of myelination. MOBP can induce experimental allergic encephalomyelitis in mice and has been proposed to have a role in the pathogenesis of multiple sclerosis. Despite 10 years of rigorous study, the normal physiological function of MOBP remains unknown. Copyright (c) 2006 S. Karger AG, Basel.
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