期刊
PROGRESS IN NEUROBIOLOGY
卷 79, 期 3, 页码 136-171出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2006.07.001
关键词
mitochondria; hypoxia; reactive oxygen species; ATP; NADH; imaging; redox state
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS045304, R01NS051856] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01 NS051856-01, R21 NS045304, R01 NS051856, R21 NS45304] Funding Source: Medline
Mitochondria are critical for cellular adenosine triphosphate (ATP) production; however, recent studies suggest that these organelles fulfill a much broader range of tasks. For example, they are involved in the regulation of cytosolic Ca2+ levels, intracellular pH and apoptosis, and are the major source of reactive oxygen species (ROS). Various reactive molecules that originate from mitochondria, such as ROS, are critical in pathological events, such as ischemia, as well as in physiological events such as long-term potentiation, neuronal-vascular coupling and neuronalglial interactions. Due to their key roles in the regulation of several cellular functions, the dysfunction of mitochondria may be critical in various brain disorders. There has been increasing interest in the development of tools that modulate mitochondrial function, and the refinement of techniques that allow for real time monitoring of mitochondria, particularly within their intact cellular environment. Innovative imaging techniques are especially powerful since they allow for mitochondrial visualization at high resolution, tracking of mitochondrial structures and optical real time monitoring of parameters of mitochondrial function. The techniques discussed include classic imaging techniques, such as rhodamine-123,
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