期刊
BIOFOULING
卷 22, 期 1, 页码 11-21出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927010500484854
关键词
biofouling; biomimetic; endothelial; microtopography; wettability; ultrahydrophobic; ulva
资金
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE013492] Funding Source: NIH RePORTER
- NIDCR NIH HHS [R01 DE 13492-01] Funding Source: Medline
Bioadhesion and surface wettability are influenced by microscale topography. In the present study, engineered pillars, ridges and biomimetic topography inspired by the skin of fast moving sharks (Sharklet AF (TM)) were replicated in polydimethylsiloxane elastomer. Sessile drop contact angle changes on the surfaces correlated well (R 2 = 0.89) with Wenzel and Cassie and Baxter's relationships for wettability. Two separate biological responses, i.e. settlement of Ulva linza zoospores and alignment of porcine cardiovascular endothelial cells, were inversely proportional to the width (between 5 and 20 mu m) of the engineered channels. Zoospore settlement was reduced by similar to 85% on the finer ( ca 2 mu m) and more complex Sharklet AF (TM) topographies. The response of both cell types suggests their responses are governed by the same underlying thermodynamic principles as wettability.
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