期刊
TOXICOLOGY AND INDUSTRIAL HEALTH
卷 22, 期 1, 页码 39-46出版社
SAGE PUBLICATIONS INC
DOI: 10.1191/0748233706th242oa
关键词
aluminium; brain; cholinesterase; cytochrome oxidase; glucose-6-phosphate dehydrogenase; motor and memory function tests
This investigation gives detailed analysis of peripheral marker enzymes as well as neurobehavioral tests following chronic aluminium (Al) exposure (10 mg/kg b.w. for 12 weeks intragastrically). We observed a significant decrease in the levels of serum cholinesterase after toxicity. The enzymatic activity of cytochrome oxidase (CO), the terminal enzyme of the electron transport chain, was significantly diminished and that of glucose-6-phosphate dehydrogenase (G-6-PD) was significantly enhanced. Neuromuscular co-ordination was assessed using motor and memory function tests. Deficits were observed suggesting a probable model for chronic Al neurotoxicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据