期刊
AUDIOLOGY AND NEURO-OTOLOGY
卷 11, 期 6, 页码 389-402出版社
KARGER
DOI: 10.1159/000095966
关键词
cochlear implant; electrically evoked action potential; recovery function; forward masking; masker-probe interval; absolute refractory period; neural response telemetry
Intracochlear recordings in cochlear implant recipients provide access to the electrically evoked compound action potential (ECAP). ECAP thresholds are potential predictors of speech processor map's threshold and comfortable loudness levels. The auditory nerve's refractory properties can influence these levels due to high-rate stimulation with interpulse intervals within the relative refractory period. Recovery functions were investigated at 84 stimulation sites in 14 Nucleus CI24 recipients using neural response telemetry and a modified forward masking technique. This technique introduces a reference masker-probe interval (MPI). In our study, an appropriate value between 300 and 375 mu s was determined for this reference MPI, and the use of a reference MPI of 300 mu s is suggested for recovery and amplitude growth functions. A median absolute refractory period of about 390 mu s and a median time constant of about 425 mu s were obtained by fitting an exponential model to the data. Hence, the auditory nerve is usually in relative refractory state when standard neural response telemetry forward masking is selected because of its default MPI of 500 mu s. This can bias the measurement of ECAP thresholds. Additionally, the shape of standard forward masking recovery functions was explained by the influence of latency shift of the neural response. Copyright (C) 2006 S. Karger AG, Basel.
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