期刊
NEUROMOLECULAR MEDICINE
卷 8, 期 4, 页码 547-565出版社
HUMANA PRESS INC
DOI: 10.1385/NMM:8:4:547
关键词
brain development; Dynein; LIS1; lissencephaly; male sterility; microcephaly; PAFAH; reelin; schizophrenia; virus
资金
- FIC NIH HHS [R03TW007048] Funding Source: Medline
- FOGARTY INTERNATIONAL CENTER [R03TW007048] Funding Source: NIH RePORTER
Lissencephaly (LIS1) was the first gene implicated in the pathogenesis of type-1 lissencephaly. More than a decade of research by multiple laboratories has revealed that LIS1 is a key node protein, which participates in several pathways, including association with the molecular motor cytoplasmic dynein, the reelin signaling pathway, and the platelet-activating factor pathway. Mutations in LIS1-interacting proteins, either in human, or in mouse models has suggested that LIS1 might play a role in the pathogenesis of numerous diseases such as male sterility, schizophrenia, neuronal degeneration, and viral infections.
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