期刊
JOURNAL OF ENDOCRINOLOGY
卷 226, 期 2, 页码 M13-M27出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JOE-15-0078
关键词
corticosteroids; circadian rhythms; neuroendocrinology; brain; memory
资金
- JSPS
- Grants-in-Aid for Scientific Research [26430006, 15J08755] Funding Source: KAKEN
The corticosterone (CORT) level changes along the circadian rhythm. Hippocampus is sensitive toCORT, since glucocorticoidreceptors are highly expressed. In rat hippocampus fixed in a living state every 3 h, we found that the dendritic spine density of CA1 pyramidal neurons increased uponwaking(within 3 h), as compared with the spine density in the sleep state. Particularly, the large-head spines increased. The observed change in the spine density may be due to the change in the hippocampal CORT level, since the CORT level at awake state (similar to 30 nM) in cerebrospinal fluid was higher than that at sleep state (similar to 3 nM), as observed from our earlier study. In adrenalectomized (ADX) rats, such a wake-induced increase of the spine density disappeared. S.c. administration of CORT into ADX rats rescued the decreased spine density. By using isolated hippocampal slices, we found that the application of 30 nM CORT increased the spine density within 1 h and that the spine increase was mediated via PKA, PKC, ERK MAPK, and LIMK signaling pathways. These findings suggest that the moderately rapid increase of the spine density on waking might mainly be caused by the CORT-driven kinase networks.
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