期刊
BLOOD
卷 107, 期 1, 页码 106-110出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2005-05-1955
关键词
-
类别
资金
- NATIONAL CANCER INSTITUTE [R01CA058343, P30CA023108] Funding Source: NIH RePORTER
- NCI NIH HHS [CA58343, CA23108, R01 CA058343] Funding Source: Medline
Runx1 expression marks the putative hemogenic endothelium between embryonic days (E) 8.5 to 11.5 of mouse gestation and is required for the formation of intra-aortic hematopoietic clusters, leading to the hypothesis that Runx1 is required for the transition from endothelial to hematopoietic cell. To address this hypothesis, we ablated the Runx1 gene by Cre-recombinase-mediated excision, with Cre expression under the control of the Tek promoter and enhancer. Most embryos died between E12.5 and El with a phenotype almost identical Runx1 deficiency. We conclude that Runx1 function in establishing definitive hematopoiesis is required in a Tek(+) cell.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据