期刊
EUROPEAN HEART JOURNAL
卷 27, 期 2, 页码 150-156出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehi582
关键词
coronary artery disease; tissue inhibitor of metalloproteinase-1; prognosis
Aims Metalloproteinases are proteolytic enzymes, which decompose the extracellular matrix, influence cardiac remodelling, and are inhibited by tissue inhibitor of metalloproteinases (TIMPs). Little is known about the prognostic impact of the TIMP-1/matrix metalloproteinase complex in patients with future cardiovascular death. Methods and results In 1979 patients with suspected coronary artery disease (CAD), TIMP-1 has been determined at baseline. Among 1945 (98.4%) patients with a mean follow-up period of 2.6 +/- 1.2 years, 75 patients died because of cardiovascular causes. Mean concentrations of TIMP-1 were higher among patients who experienced a fatal cardiovascular event than among those who did not (820 vs. 692 ng/mL; P < 0.001). Age and sex adjusted hazard ratio of future cardiovascular death associated with one standard deviation of TIMP-1 level, was 1.37 (95% CI: 1.17-1.61; P < 0.001). The hazard ratio remained nearly identical after adjustment for clinical and therapeutic confounders. B-type natriuretic peptide (2.75, 95% CI: 1.94-3.89; P < 0.001), C-reactive protein (1.79, 95% CI: 1.43-2.24; P < 0.001), and TIMP-1 (1.30, 95% CI: 1.07-1.58; P=0.008) were independently associated with future cardiovascular death. Conclusion In patients with CAD, TIMP-1 proves as an independent predictor for future cardiovascular death.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据