期刊
JOURNAL OF ENDOCRINOLOGY
卷 228, 期 1, 页码 25-37出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JOE-15-0391
关键词
trout; fish; food intake; ghrelin; fatty acid; hypothalamus
资金
- Ministerio de Economia y Competitividad (Spain) [BES-2011-043394, BES-2014-068040]
- European Fund for Regional Development [AGL2013-46448-C3-1-R, AGL2013-46448-C3-3-R]
There is no information available on fish as far as the possible effects of ghrelin on hypothalamic fatty acid metabolism and the response of fatty acid-sensing systems, which are involved in the control of food intake. Therefore, we assessed in rainbow trout the response of food intake, hypothalamic fatty acid-sensing mechanisms and expression of neuropeptides involved in the control of food intake to the central treatment of ghrelin in the presence or absence of a long-chain fatty acid such as oleate. We observed that the orexigenic actions of ghrelin in rainbow trout are associated with changes in fatty acid metabolism in the hypothalamus and an inhibition of fatty acid-sensing mechanisms, which ultimately lead to changes in the expression of anorexigenic and orexigenic peptides resulting in increased orexigenic potential and food intake. Moreover, the response to increased levels of oleate of hypothalamic fatty acid-sensing systems (activation), expression of neuropeptides (enhanced anorexigenic potential) and food intake (decrease) were counteracted by the simultaneous treatment with ghrelin. These changes provide evidence for the first time in fish of a possible modulatory role of ghrelin on the metabolic regulation by fatty acid of food intake occurring in the hypothalamus.
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