期刊
ANALYTICAL METHODS
卷 7, 期 15, 页码 6419-6425出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ay00732a
关键词
-
资金
- National Natural Science Foundation of China [21342012, 21375037]
- Hunan Provincial Natural Science Foundation of China [11JJ3023, 15JJ3094]
- Science and Technology Department [13JJ2020]
- State Key Laboratory of Chemo/Biosensing and Chemometrics Foundation [KLCBTC MR 2011-05]
- Scientific Research Fund of Hunan Provincial Education Department [13C635]
A simple and new fluorescent and colorimetric probe bearing 7-nitrobenz-2-oxa-1,3-diazole and 4-maleimidophenol fragments for biothiols was designed and synthesized. The probe itself showed almost no background fluorescence (Phi(F) < 1 x 10(-4)) and displayed fluorescence turn-on response with selectivity for thiols over other relevant biological species in aqueous solutions. In addition, the probe exhibited 110 nm red-shifted absorption spectra accompanied by color changes which could be obviously distinguished by the naked eye. Furthermore, the probe showed high sensitivity towards thiols with a detection limit of 1.2 x 10(-7) M (S/N = 3) and the mechanism regarding the optical responses of the probe to thiols was explained by density function theory (DFT) calculations. Finally, the probe has been successfully used to image thiols in HeLa cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据