期刊
ANALYTICAL METHODS
卷 7, 期 18, 页码 7455-7460出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ay01880c
关键词
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资金
- National Natural Science Foundation of China [21373138, 21302125]
- Shanghai Education Committee [15ZZ070]
- Shanghai Sci. & Tech. Committee [12JC1407200]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1269]
- International Joint Laboratory on Resource Chemistry (IJLRC)
Mercury (Hg2+) is a toxic heavy metal and commonly exists in the ecological environment and polluted biological samples. Small-molecular-weight biological thiols (biothiols, such as GSH and Cys) play an essential role in many biological events. Till now, recently developed approaches for monitoring Hg2+ and biothiols commonly require large and cumbersome instruments, complicated procedures, or an elegant design and synthesis. In this study, we have developed a dynamic light scattering (DLS) based technique for the dual detection of Hg2+ and biothiols. This label free assay based on DNA-mediated gold nanoparticles (DNA-AuNPs) could present an effective toolkit for the determination of Hg2+ (or biothiol) containing samples within 30 min without complicated procedures. To best of our knowledge, this is the first DLS based probe for the dual detection of Hg2+ and biothiols. It exhibited potential for high throughput screening of Hg2+ (or biothiol) containing samples.
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