期刊
JOURNAL OF NEUROCHEMISTRY
卷 97, 期 6, 页码 1634-1658出版社
WILEY
DOI: 10.1111/j.1471-4159.2006.03907.x
关键词
free radical; hydroxyl radical; proteasome; protein aggregation; reactive oxygen species; superoxide
The brain and nervous system are prone to oxidative stress, and are inadequately equipped with antioxidant defense systems to prevent 'ongoing' oxidative damage, let alone the extra oxidative damage imposed by the neurodegenerative diseases. Indeed, increased oxidative damage, mitochondrial dysfunction, accumulation of oxidized aggregated proteins, inflammation, and defects in protein clearance constitute complex intertwined pathologies that conspire to kill neurons. After a long lag period, therapeutic and other interventions based on a knowledge of redox biology are on the horizon for at least some of the neurodegenerative diseases.
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