期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 1, 页码 221-224出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.09.009
关键词
chrysin; Oroxylum indicum; spacers; antibacterial activity; amines
The natural product, chrysin (5,7-dihydroxy flavone), obtained from Oroxylum indicum, exhibits numerous biological activities including anticancer, anti-inflammatory, and antiallergic activities. Three series of chrysin analogues were prepared, in which chrysin and heterocyclic moieties are separated by 3-carbon, 4-carbon, and 6-carbon spacers. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that most of the derivatives displayed significant activity as compared to their parent compound (chrysin). (c) 2005 Elsevier Ltd. All rights reserved.
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