期刊
BIOLOGICAL PSYCHIATRY
卷 59, 期 1, 页码 1-6出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2005.06.015
关键词
autism; MRI; brain; tissue volume; neuroimaging; adolescent/adult
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P30HD003110] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH061696] Funding Source: NIH RePORTER
- NICHD NIH HHS [5 P30 HD03110] Funding Source: Medline
- NIMH NIH HHS [MH61696] Funding Source: Medline
Background: A number of studies have found brain enlargement in autism, but there is disagreement as to whether this enlargement is limited to earl); development or continues into adulthood. In this study, cortical gray and white tissue volumes were examined in a sample of adolescents and adults with autism who bad demonstrated total brain enlargement in a previous magnetic resonance imaging (MRI) study. Methods: An automated tissue segmentation program was applied to structural M-RI scans to obtain volumes of gray, white, and cerebrospinal fluid (CSF) tissue on a sample of adolescent and adult males ages 13-29 with autism (h = 23) and controls (n = 15). Regional differences for brain lobes and brain hemispheres were also examined. Results: Significant enlargement in gray matter volume was found for the individuals with autism, with a disproportionate increase in left-sided gray matter volume. Lobe volume enlargements were detected for frontal and temporal, but not parietal or occipital lobes, in the subjects with autism. Age and nonverbal IQ effects on tissue volume were also observed. Conclusions: These findings give evidence for left-lateralized gray tissue enlargement in adolescents and adults with autism, and demonstrate a regional pattern of cortical lobe volumes underlying this effect.
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