期刊
JOURNAL OF HEPATOLOGY
卷 44, 期 -, 页码 S19-S24出版社
ELSEVIER
DOI: 10.1016/j.jhep.2005.11.009
关键词
hepatitis C; cirrhosis; fibrosis; natural history
Cirrhosis is the end-stage consequence of fibrosis progression in patients with chronic hepatitis C. The median time from infection to cirrhosis is 30 years, with a high inter-individual variability, which is now better understood. Several factors have been clearly shown to be associated with fibrosis progression rate: duration of infection, age, male gender, alcohol consumption, HIV co-infection and low CD4 count. Metabolic conditions such as steatosis, being overweight and diabetes are emerging as independent co-factors of fibrogenesis. The recent validation of non-invasive biomarkers should facilitate the study of fibrosis progression in large populations. (c) 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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