期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 1, 页码 49-54出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.09.060
关键词
thiazoles; Stille reactions; Suzuki reactions; nuclear receptors; PPAR
Sequential, position-selective, Pd-catalyzed cross-coupling reactions of 2,4-dibromo-5-hydroxymethylthiazole provided the scaffold for the synthesis of GW501516, the most potent PPAR beta/delta agonist yet described, and equally selective analogs at the thiazole-C4 position. (c) 2005 Elsevier Ltd. All rights reserved.
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