期刊
CHEMICAL COMMUNICATIONS
卷 -, 期 27, 页码 2848-2850出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b607324g
关键词
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The first total synthesis of MCoTI-II, a cysteine knot microprotein and potent trypsin inhibitor, is described; a synthetic strategy has been developed that combines efficient backbone construction via optimised solid phase peptide synthesis with one-pot 'thia-zip' native chemical ligation and refolding to yield the natural product.
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