期刊
ANNALS OF THORACIC SURGERY
卷 81, 期 1, 页码 366-368出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.athoracsur.2004.07.084
关键词
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Thymic carcinoids are classified into three categories: (1) nonsecretory tumors, (2) hormonal secretory tumors, and (3) tumors associated with multiple endocrine neoplasia type 1. We report a rare case with adrenocorticotropic hormone secreting thymic carcinoid with multiple endocrine neoplasia type 1. Radiologic examination showed an anterior mediastinal mass and a parathyroid tumor. Blood analysis revealed high levels of parathyroid hormone and adrenocorticotropic hormone. Urine cortisol and 17-hydroxycorticoids levels were also elevated. Extended thymectomy was performed. Subsequently adjuvant radiation therapy and parathyroid tumor resection were performed. A germline mutation of exon 7 in the multiple endocrine neoplasia type I gene was detected and a somatic mutation of exon 9 was demonstrated in the thymic tumor.
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