期刊
CHEMICAL COMMUNICATIONS
卷 -, 期 11, 页码 1185-1187出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b516575j
关键词
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Amiloride (N-amidino-3,5-diamino-6-chloro-pyrazinecarboxamide hydrochloride) has two sets of hydrogen-bond forming sites suitable for target nucleotides and the phosphodiester DNA backbone by which a thymine base opposite an abasic site in DNA duplexes can be recognized with high selectivity and affinity, and it is applicable to the fluorescence detection of thymidine-related SNPs (single-nucleotide polymorphisms) of PCR amplification products.
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