期刊
ONCOGENE
卷 25, 期 27, 页码 3801-3809出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1209561
关键词
DNA microarray; gene expression profile; hepatocellular carcinoma (HCC); comparative functional genomics; integrative functional genomics
资金
- NATIONAL CANCER INSTITUTE [Z01SC010385] Funding Source: NIH RePORTER
Global gene expression pro. ling of hepatocellular carcinoma (HCC) is a promising new technology that has already refined the diagnosis and prognostic predictions of HCC patients. This has been accomplished by identifying genes whose expression pattern is associated with clinicopathological features of HCC tumors. Molecular characterization of HCC from gene expression pro. ling studies will undoubtedly improve the prediction of treatment responses, selection of treatments for specific molecular subtypes of HCC and ultimately the clinical outcome of HCC patients. The research focus is now shifting toward the identification of genetic determinants that are components of the specific regulatory pathways altered in cancers, and that may constitute novel therapeutic targets. Here we review the recent advances in gene expression pro. ling of HCC and discuss the future strategies for analysing large and complicated data sets from microarray studies and how to integrate these with diverse genomic data.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据