期刊
BIOPHYSICAL JOURNAL
卷 90, 期 1, 页码 65-76出版社
CELL PRESS
DOI: 10.1529/biophysj.105.071480
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资金
- NIGMS NIH HHS [R01 GM075305, GM075305] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM075305] Funding Source: NIH RePORTER
Motile cells explore their surrounding milieu by extending thin dynamic protrusions, or filopodia. The growth of. lopodia is driven by actin filament bundles that polymerize underneath the cell membrane. We compute the mechanical and dynamical features of the protrusion growth process by explicitly incorporating the flexible plasma membrane. We find that a critical number of filaments are needed to generate net. lopodial growth. Without external in. fluences, the. lopodium can extend inde. nitely up to the buckling length of the F-actin bundle. Dynamical calculations show that the protrusion speed is enhanced by the thermal. uctuations of the membrane; a filament bundle encased in a flexible membrane grows much faster. The protrusion speed depends directly on the number and spatial arrangement of the filaments in the bundle and whether the. laments are tethered to the membrane. Filopodia also attract each other through distortions of the membrane. Spatially close filopodia will merge to form a larger one. Force-velocity relationships mimicking micromanipulation experiments testing our predictions are computed.
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