期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 14, 期 1, 页码 17-24出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2005.07.057
关键词
marine sponges; natural products; bromopyrrole alkaloids; Axinella verrucosa; neuroprotective activity
The Mediterranean sponge Axinella verrucosa has been investigated for its alkaloid composition and has been found to produce a complex mixture of bromopyrrole alkaloids. Along with the previously isolated compounds 5-18, four novel alkaloids of this class, Compounds 1-4, have been isolated, and their Structures established through spectroscopic methods. Compounds 1-4 were found to display neuroprotective activity against the agonists scrotonin and glutamate in vitro. (c) 2005 Elsevier Ltd. All rights reserved.
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