期刊
BIOPHYSICAL JOURNAL
卷 90, 期 2, 页码 668-671出版社
CELL PRESS
DOI: 10.1529/biophysj.105.065599
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资金
- NIGMS NIH HHS [R01 GM033289, GM33289] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM033289] Funding Source: NIH RePORTER
When single-molecule fluorescence localization techniques are pushed to their lower limits in attempts to measure ever-shorter distances, measurement errors become important to understand. Here we describe the non-Gaussian distribution of measured distances that is the key to proper interpretation of distance measurements. We test it on single-molecule high-resolution colocalization data for a known distance, 10 nm, and find that it gives the correct result, whereas interpretation of the same data with a Gaussian distribution gives a result that is systematically too large.
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