期刊
ANNALS OF NEUROLOGY
卷 59, 期 1, 页码 174-177出版社
WILEY-LISS
DOI: 10.1002/ana.20688
关键词
-
资金
- NIMH NIH HHS [Z01 MH002796-04, 2D1 MH 002796-04] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [Z01MH002852, Z01MH002796, Z01MH002795] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [Z01NS002265] Funding Source: NIH RePORTER
Objective: Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects. Methods: Nicotinic acetylcholine receptors were imaged in 10 nondemented Parkinson's disease patients and 15 age-matched healthy subjects using a single-photon emission computed tomography ligand [I-123]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine. Using an arterial input function, we measured the total distribution volume (V; specific plus nondisplaceable), as well as the delivery (K,). Results. Parkinson's disease showed a widespread significant decrease (approximately 10%) of V in both cortical and subcortical regions without a significant change in K-1. Interpretation: These results indicate the importance of extending the study to demented patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据