期刊
NEUROSCIENCE
卷 139, 期 1, 页码 311-316出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2005.04.071
关键词
distance effects; magnitudes; prefrontal cortex; temporal order; short-term memory; neuroimaging
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH060655] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG018286] Funding Source: NIH RePORTER
- NIA NIH HHS [AG 18286] Funding Source: Medline
- NIMH NIH HHS [MH 60655] Funding Source: Medline
Memory for order information has been tied to the frontal lobes, however, parietal activation is observed in many functional neuroirnaging studies. Here we report functional magnetic resonance findings from an event-related experiment involving working memory for order. Five letters were presented for storage, followed after a delay by two probe items. Probe items could be separated by zero to three positions in the memory set and subjects had to indicate whether the items were in the correct order. Analyses indicate that activation in left parietal cortex shows a systematic decrease in activation with increasing probe distance. This finding is consistent with an earlier study in which we suggested that parietal cortical regions mediate the representation of order information via magnitude codes. (C) 2005 Published by Elsevier Ltd on behalf of IBRO.
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