期刊
DRUG METABOLISM REVIEWS
卷 38, 期 4, 页码 805-853出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03602530600952222
关键词
styrene; biotransformation; DNA and chromosomal damage; genetic polymorphisms; DNA repair
This report reviews styrene biotransformation, including minor metabolic routes, and relates metabolism to the genotoxic effects and possible styrene-related carcinogenicity. Styrene is shown to require metabolic activation in order to become notably genotoxic and styrene 7,8-oxide is shown to contribute quantitatively by far the most (in humans more titan 95%) to the genotoxicity of styrene, while minor ring oxidation products are also shown to contribute to local toxicities, especially in the respiratory system. Individual susceptibility depending on metabolism polymorphisms and individual DNA repair capacity as well as the dependence of the nonlinearity of the dose-response relationships in the species in question and the consequences for risk evaluation are analyzd.
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