期刊
GENETICS
卷 173, 期 2, 页码 1125-1133出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.105.052720
关键词
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资金
- NHGRI NIH HHS [HG002790-01A1, P50 HG002790] Funding Source: Medline
- NIGMS NIH HHS [R01 GM069890] Funding Source: Medline
- PHS HHS [FM069890-01A1] Funding Source: Medline
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [P50HG002790] Funding Source: NIH RePORTER
We develop methods for exploiting single-feature polymorphism data, generated by hybridizing genomic DNA to oligonucleotide expression arrays. Our methods enable the use of such data, which can be regarded as very high density, but imperfect, polymorphism data, for genomewide association or linkage disequilibrium mapping. We use a simulation-based power study to conclude that our methods should have good power for organisms like Arabidopsis thaliana, in which linkage disequilibrium is extensive, the reason being that the noisiness of single-feature polymorphism data is more than compensated for by their great number. Finally, we show how power depends on the accuracy with which single-feature polymorphisms are called.
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