期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 100, 期 6, 页码 1983-1991出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01169.2005
关键词
synthetic metalloporphyrin; nitric oxide activity; in situ hybridization; nitrergic tone; appetite
资金
- NCI NIH HHS [P30 CA-22435] Funding Source: Medline
- NIDDK NIH HHS [R01 DK-53479] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA022435] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK053479] Funding Source: NIH RePORTER
Administration of cobaltic protoporphyrin IX (CoPP) into the third ventricle of the brain by intracerebroventricular injection in rodents is known to result in transient hypophagia and remarkably prolonged weight loss. The mechanism of action of CoPP in eliciting these effects is unknown. It is known that nitric oxide plays a role in food intake and that the hyperphagia that results from a wide variety of genetic, physiological, and pharmacological stimuli can be blocked by the administration of inhibitors of the enzyme nitric oxide synthase (NOS). We demonstrate that intracerebroventricular administration of compounds that alter nitrergic tone can also change food ingestion and weight gain patterns in normophagic rats. We also demonstrate that CoPP decreases NOS activity but that it paradoxically increases neuronal NOS transcript expression and increases neuronal NOS protein content on Western blotting.
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