期刊
FREE RADICAL RESEARCH
卷 40, 期 6, 页码 659-664出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760600615649
关键词
antioxidants; carotenoids; lycopene; myocardial infarction; retinol; risk factors
Background: Carotenoids may reduce the risk of coronary heart disease through their antioxidant properties, but the results of epidemiological studies are controversial. We analysed the relation between the intake of selected carotenoids and retinol and risk of acute myocardial infarction (AMI). Methods: A case-control study was conducted in Milan, Italy, in 1995-2003. Cases were 760 patients with nonfatal AMI, and controls 682 patients admitted to hospital. Results: The risk of AMI decreased with increasing intake of alpha-carotene (odds ratios, OR 0.71, 95% confidence intervals, CI 0.51-0.98, for the highest vs the lowest quartile of intake), beta-carotene (OR 0.71, 95% CI 0.50-1.01) and beta-criptoxanthin (OR 0.64, 95% CI 0.46-0.88). No associations emerged for total carotenoids, lycopene, lutein plus zeaxanthin and retinol. Conclusions: Our study suggests a weak protective effect of alpha-carotene, beta-carotene and beta-criptoxanthin on the risk of AMI. It also indicates that total carotenoids, lycopene, lutein plus zeaxanthin and retinol were not related to the risk of the disease.
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