期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 23, 期 2, 页码 587-590出版社
WILEY
DOI: 10.1111/j.1460-9568.2005.04584.x
关键词
auditory brainstem response; bilateral sensorineural hearing loss; inner ear; syndromic hearing loss
It has been reported that mutations in the gene encoding human insulin-like growth factor-I (IGF-I) cause syndromic hearing loss. To study the precise role of IGF-I in auditory function and to hypothesize the possible morphological and electrophysiological changes that may occur in the human inner ear, we have analysed the auditory brainstem response in a mouse model of IGF-I deficiency. We show here that homozygous Igf-1(-/-) mice present an all-frequency involved bilateral sensorineural hearing loss. Igf-1(-/-) mice also present a delayed response to acoustic stimuli; this increases along the auditory pathway, indicating a contribution of the central nervous system to the hearing loss in Igf-1(-/-) mice. These results support the use of the Igf-1(-/-) mouse as a new model for the study of human syndromic deafness.
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