期刊
CLINICAL IMMUNOLOGY
卷 118, 期 1, 页码 117-123出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2005.08.015
关键词
thymus; involution; thymopoiesis; sex steroids; growth hormone; insulin-like growth factor-I; mice
类别
资金
- NATIONAL CANCER INSTITUTE [P30CA016042] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG021450] Funding Source: NIH RePORTER
- NCI NIH HHS [CA16042] Funding Source: Medline
- NIA NIH HHS [AG21450] Funding Source: Medline
The concomitant decline in growth hormone (GH) and increase in sex steroid production with age is thought to be responsible for thymic involution. If changes in the production of these hormones trigger or sustain thymic involution, that process should be accelerated in little mice, which have a genetic deficiency resulting in reduced production of thymopoietic GH, and delayed in the hypogonadal strain, which fails to produce thymocytotoxic sex steroids. The results indicated that thymic involution in both strains progressed in a manner similar to their normal littermates. That blocking sex steroid production did not delay thymic involution was surprising since castration reportedly increases thymus cellularity. Re-examination of that phenomenon revealed that, while gonadectomy results in increased thymus size, its effects are transient, and the thymus ultimately undergoes involution. Taken together, these data suggest that age-related changes in the endocrine system do not underlie thymic involution. (c) 2005 Elsevier Inc. All rights reserved.
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